Skip to content

Penicillin G Benzathine (Bicillin L-A)

What is it?

Penicillin G Benzathine is an antibiotic used to treat a variety of infections.

How to take this medication:

This drug is given by injection into a large muscle such as buttock or hip. 2 injections are needed to deliver a full dose of the medication. You may need to return for additional doses of this medication depending on your lab results. It is important to follow the recommended treatment plan and receive all doses of this medication, even if you are not having any symptoms. Missing a dose may allow the bacteria to keep growing.

Do NOT take this medication if you:

Have an allergy to any medication containing penicillin.

Have had a reaction to any medication containing penicillin.

Tell your health care provider if you:

Have an allergy or sensitivity to any medications including cephalosporins.

Have asthma.

Are pregnant or breastfeeding.

Are 65 years old or older.

Side effects:

This medication may cause side effects such as:

  • Mild diarrhea
  • Stomach upset
  • Nausea
  • Vomiting
  • Irritation at the injection sites

If these symptoms persist or worsen, inform your health care provider.

Notify your health care provider immediately if you develop:

  • Stomach cramps
  • Fever
  • Unusual bleeding or bruising
  • Yellowing of the eyes or skin
  • Unusual tiredness or weakness

As with other antibiotics, if you develop diarrhea that becomes severe and watery or does not go away, stop taking the medicine and call your health care provider. This could be a sign of a serious medical problem. Do not take over-the-counter medications to treat diarrhea without first consulting with your health care provider.

Allergic reactions are rare but can be very serious if not treated right away. If you experience any of the following symptoms, contact your health care provider right away:

  • Trouble breathing or wheezing
  • Swelling in the face, mouth and neck
  • Severe skin rash, hives or blisters

Drug interactions:

This medication should be avoided if you are taking tetracycline which is another kind of antibiotic.

Missed dose:

It is important to follow the recommended treatment plan and receive all doses of this medication, even if you are not having any symptoms. If you have missed a dose or are late receiving a dose of this medication, speak with your health care provider.

Storage:

This medication should be stored in the fridge but can be kept at room temperature for 7 days.

Points to remember:

This medication may affect certain glucose test results.